Idiopathic pulmonary fibrosis (IPF) produces scarring in the peripheral and basilar regions of the lung with macroscopically normal-appearing tissue in the central and apical areas. This study involved comparing transcriptomic profiles of the latter with transcriptomes of scarred IPF and healthy control lung tissues. The primary goal of the research was to elucidate the pathobiology of the disease in its earliest stages. Tissue samples were taken from lung explants of 3 IPF patients and healthy lung tissue from 3 transplant donors. Dataset includes 10 sequence reads from macroscopically normal-appearing areas and 8 from scarred regions from IPF lungs, and an additional 8 from the normal control tissue for a total of 26 samples. 1 supplementary PDF and 7 supplementary datasets in Excel are available at: http://dx.doi.org/10.1016/j.cellimm.2018.01.002

Mucormycosis is a life-threatening disease especially to individuals who are immunosuppressed or have chronic health conditions. Several genera within the fungal order Mucorales have been identified as causative agents. This dataset is the result of research elucidating the population genetics, phylogeny, and pathogenicity of the infectious fungi. Included are de novo genome sequences and annotations for 27 isolates of 15 species of the following genera: Apophysomyces, Cokeromyces, Cunninghamella, Mucor, Rhizomucor, Rhizopus, Saksenaea, Syncephalastrum, and Umbelopsis. With the inclusion of previously published genomes of additional strains, comparative analysis was conducted on a total of 41. To investigate Mucorales fungi-host cell responses, RNA sequencing was performed using human airway epithelial cells infected with Rhizopus delemar or Rhizopus oryzae. All sequences are available in the NCBI SRA database with additional data provided via supplementary files.

Plasmodium vivax is the most widespread human malaria parasite. However, its biology is little understood for a number of reasons, not the least of which is the inability to continuously propagate it in vitro. Utilizing samples of whole blood taken from 26 Cambodian patients who were determined to be solely infected with the parasite, this research investigated three aspects of P. vivax activity: 1) the statistical contribution of the different developmental stages present in infection using gene expression deconvolution; 2) the regulation of expression of gametocyte genes, and 3) the effect of chloroquine on the P. vivax transcriptome. The primary dataset includes RNA-sequencing reads from the blood of the Cambodian patients as well as reads derived from dissected sporozoites from mosquitoes. Four supplementary data files provide additional details from the study.

This study was undertaken to investigate the correlation between cervicovaginal microbiota, immunological factors, and race and the risk of premature birth. From a cohort of 2000 women with singleton pregnancies, 539 participated in the research with 432 delivering full term and 107 experiencing spontaneous preterm delivery. The racial breakdown consisted of 402 African American, 115 White, and 22 Other. Cervicovaginal samples and anthropomorphic measurements were collected during 3 visits: between 16-20, 20-24, and 24-28 weeks of gestation. The microbiota was characterized, immunological profiles were established, and the results evaluated according to race and delivery outcome. Data includes demographic, phenotype, clinical measures, statistical and metagenomic.